Design of Enabling-Regenerative Materials | 2 Mers Seas Zeeën

DERMA

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Design of Enabling-Regenerative Materials

Priority Axis

Technological and Social Innovation

Specific objective

Technological Innovation

Lead partner

University of Brighton

Contact

Start Date

01/09/2016

End Date

30/11/2020

Project budget

2 724 815

ERDF amount

1 634 889

ERDF rate

60%

    About

    Common challenge

    DERMA will address the common challenge of improving the quality of life of the increasing elderly population of the 2 Seas area. By 2025, more than 20% of Europeans will be 65 or older, with a large increase in those over 80. We will tackle the problem of advanced age (or illness)-associated inflammation, infection and ulceration of the skin which costs the EU €6.5 billion per year. Dermal ulcers are a source of physical discomfort, can lead to further medical complications, and can liberate offensive odours that are distressing to the patient and may lead to social isolation and depression.

    Main Achievements

    The DERMA project has developed novel dressing materials intended for the improved management of chronic dermal ulcers. In such wounds, infection and inflammation can cause skin tissue to breakdown, often producing offensive odours. These wounds can be painful, and the malodour embarrassing for the patient, potentially leading to social isolation and depression. Chronic wounds may also be subjected to a series of underlying infections that the body does not easily eradicate and that require clinical intervention.

    To meet these twin challenges of malodour production and infection, the project has developed two types of materials; the first to manage unpleasant odours from a wound, and the second to visually indicate the emergence of a developing infection.

    The materials to combat wound malodour have used activated carbon (AC) granules as the active ingredient. One form is a thin film made by combining AC with agarose from seaweed that has been treated to be flexible and elastic and able to fit the contours of the skin. In tests, volunteers found that the DERMA material was significantly better at masking a bacteria-like odour than control materials. The material has been augmented to have a fluid handling capability to make it potentially suitable for use on sloughy wounds which can otherwise cause damaging tissue maceration.

    AC for odour control has also been incorporated into very fine, electrospun fibres with a large surface area for odour removal. These proprietary fibres are highly water absorbent, of benefit for wound moisture control. The fibres also have a remarkable ability to release antimicrobial agents over extended periods, meaning that, in the form of a wound dressing, they could potentially be more efficient than current materials.
    To indicate the presence of an infection, a bacterial growth indicator dye, resazurin, has been incorporated into a biodegradable, transparent film. The dye changes colour from blue to bright pink when exposed to growing bacteria and is intended to provide an early warning that an infection is developing, and that intervention is required. The release of the dye from the film has been controlled such that the dye should remain visible in the dressing when applied to a patient.

    Resazurin was also successfully entrapped within a molecule called cyclodextrin, adding further control to its release and allowing it to be electrospun to produce a fibrous, swellable material intended for the detection of infections.

    Partnership

    Partners

    University of Portsmouth

    Universiteit Gent

    Eurasanté

    Outputs

    Output name
    Type
    Target
    URL / Download
    01/12/2020

    DERMA

    Theme: Technological innovationHealth care
    Type: Prototype
    Target: Health institutions
    30/04/2020

    DERMA

    Theme: Technological innovationHealth care
    Type: Method/service
    Target: Health institutions
    30/04/2020

    DERMA

    Theme: Technological innovationHealth care
    Type: Method/service
    Target: Health institutions
    01/03/2020

    DERMA

    Theme: Technological innovationHealth care
    Type: Prototype
    Target: Health institutions
    03/01/2020

    DERMA

    Theme: Technological innovationHealth care
    Type: Prototype
    Target: Health institutions
    03/01/2020

    DERMA

    Theme: Technological innovationHealth care
    Type: Feasibility study
    Target: Health institutions
    03/01/2020

    DERMA

    Theme: Technological innovationHealth care
    Type: Feasibility study
    Target: Health institutions
    01/12/2019

    DERMA

    Theme: Technological innovationHealth care
    Type: Prototype
    Target: Health institutions