Health for Dairy Cows | 2 Mers Seas Zeeën

H4DC

Vous êtes ici

Health for Dairy Cows

Priority Axis

Technological and Social Innovation

Specific objective

Technological Innovation

Lead partner

YNCREA

Date de début

01/03/2019

Date de fin

31/03/2023

Project budget

3 715 874

ERDF amount

2 229 524

ERDF rate

60%

    À propos

    Common challenge

    Animal diseases such as Cryptosporidiosis can also pose a threat to human health. Human outbreaks can occur from water collected in areas contaminated by bovine stools. In cattle farms, this common illness is difficult to control without good breeding practices, efficient detection tools or effective pharmaceuticals. Young infected animals spread millions of parasites a day and show stunted growth. This disease leads to a higher mortality rate, which further threaten the economic viability of a sector which already faces frequent crises. By reducing the impact of cryptosporidiosis in farms, our project aims to increase farm productivity in a number of different countries, making these businesses more efficient and successful, with a lower impact on human health. For this purpose, this project aims to provide pilot farms, detection tools and technological devices that can accelerate the discovery of new drugs at the lowest possible cost.

    Main Achievements

    H4DC project started in March 2019. Since that date, 4 months were spent to obtain duly signed administrative documents (Partnership agreement, Public Procurement Policy).

    The kick off meeting was rapidly organized in Lille and completed with a start meeting in Canterbury to initiate first work steps. This meeting was also a time to write out the monitoring plan. We directly started to hire technician (PP7), PhD students (LP, PP3) and post doc candidates (LP, PP3). This procedure spread over 1 to 6 months because of good candidates’ lack.

    WP 5 started with Rollup, Poster, Website design, Scientific conferences (IGCC, IPTA, Apicowplexa) and professional fair (Vetel) participations. We made animations and video shootings to present strategies and partnership within the 2 seas programme context. 

    WP1 was initiated with the redaction of information sheet, an agreement document and exhaustive questionnaire on farm practices (LP, PP3, PP4, PP5, PP6, PP7). Afterward, PP4 and PP5 actively recruited farmers and started interviews and sampling. Samples are currently analysed by LP and PP3 with first genetic results obtained for Dutch samples. PP6 delayed farm recruitment because of ethical problem. Several contacts with European administrator and LP led to circumvent this issue. Vets from RVC were not available during H4DC starting period. Following a meeting in London with PP3 and LP, the solution to delay this experimental step was decided. The test kit building started. Following sequence analysis, list of target proteins was reduce from 10 to 4 good candidates by PP3. Finally, PP7 identified from scientific literature keys factors that contribute to the risk of parasite infection.

    Regarding WP2, PhD students were trained on cell culture and parasite infection. LP, PP2, PP3 shared their methods, cell types and devices. Thanks to the configuration of a server, data from microscopy started to be shared. The engineering of fluorescent cell line for drug screening was completed (PP3).

    The WP3 started by the creation of a contact database and the redaction of an IPR document.

    During this first year, management was done with the target to ease administrative constraints and communication between partners. This strategy led also to increase cross border cooperation through co working session (i.e : questionnaire redaction) and data/material/knowledge sharing between partners.

    (H4DC project has just started and no outputs nor Specific objectives were reached.)

    Partnership

    Partners

    National Center for Scientific Research (CNRS)

    University of Kent

    InAgro

    Southern Dutch Farmer and Horticulturists Organization

    SelasCVE

    University of East Anglia